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[Feb 23, 2026] US Pre-market: Alphabet’s AI Upgrade vs. Novo Nordisk’s Weight-Loss Setback

Feb 23, 2026: Wells Fargo upgrades Alphabet on Cloud/AI surge. Novo Nordisk’s CagriSema fails to beat Eli Lilly in trials.

 

■ Big Tech & AI Infrastructure

Alphabet (GOOGL, GOOG)

  • Wells Fargo Upgrade: Upgraded from Equal Weight to Overweight, raising the price target from $354 to $387.

  • Computing Power Surge: Alphabet’s computing capacity was 15GW at the end of 2025; management plans to expand this to 35GW by 2028.

  • Revenue Outlook: Based on this expansion, Wells Fargo projects Google Cloud revenue growth of 60% for 2026, 42% for 2027, and 28% for 2028—all 10 percentage points above consensus.

  • Gemini Subscriptions: Subscription revenue is expected to soar from $4B in 2025 to $12B by the end of 2027. The AI partnership with Apple's Siri further supports this bullish outlook.

Meta Platforms (META)

  • Fiber Optic Demand: UBS notes that Meta’s massive Capex increase will drive further demand for Corning’s (GLW) fiber products. Analysts believe growth will remain high through the mid-2030s.


■ Healthcare & Biotech Movers

Novo Nordisk (NVO)

  • Clinical Setback: Its next-gen weight-loss drug CagriSema failed to prove "non-inferiority" against Eli Lilly’s Tirzepatide in an 84-week Phase 3 trial.

  • The Numbers: CagriSema (2.4mg) achieved a 23% average weight loss, while Tirzepatide (15mg) achieved 25.5%. The company plans to conduct follow-up trials with higher dosages to re-evaluate potential.

Gilead Sciences (GILD)

  • Major Acquisition: Announced it will acquire cancer-focused biotech Arcellx (ACLX) for approximately $7.8 billion ($115/share plus a $5 CVR).

Johnson & Johnson (JNJ)

  • Tremfya Success: Reported that 80.8% of patients achieved clinical remission at week 140. No new safety issues were observed, reconfirming long-term efficacy.


■ Consumer & Media Strategy

Domino’s Pizza (DPZ)

  • Earnings Beat (Revenue): Reported Q4 revenue of $1.54B (vs. $1.52B est), though adjusted EPS ($5.35) slightly missed the $5.39 estimate.

  • Dividend Hike: Approved a 15% increase in the quarterly dividend to $1.99 per share.

  • Growth: Added 392 new stores globally in the quarter; US same-store sales grew 3.7%.

Paramount (PSKY) & Warner Bros. Discovery (WBD)

  • Takeover Deadline: Today is the final deadline for Paramount/Skydance to submit its bid for WBD. Recent proposals offer $30/share, higher than Netflix’s $27.75 offer.


■ Software Sector: AI Disruption & Valuation Re-rating

Jefferies and BNP Paribas are taking a cautious stance on software due to AI competition risks.

TickerActionReason
Workday (WDAY)Downgrade to HoldManagement transition risks and medium-term growth concerns.
DocuSign (DOCU)Downgrade to HoldSlower recovery of double-digit growth; IAM platform unproven.
monday.com (MNDY)Downgrade to HoldUnclear growth prospects in the SMB segment.
Freshworks (FRSH)Downgrade to HoldAI risk in core customer experience sectors.
Snowflake (SNOW)PT Cut ($312 → $235)Difficulty attracting new customers vs. expanding existing ones.
  • BNP Paribas Analysis: Re-evaluating SaaS companies by adjusting FCF for Stock-Based Compensation (SBC). They identify ServiceNow (NOW) and Adobe (ADBE) as having the most upside, while Zoom (ZM) and Snowflake (SNOW) face downward valuation pressure.


■ Hardware & Industrial Updates

  • Dell Technologies (DELL): BofA maintained a Buy but lowered the target to $135 (from $150). Rising memory costs are expected to pressure margins, despite strong demand for AI servers.

  • Autodesk (ADSK): Morgan Stanley lowered its target to $350 ahead of earnings, focusing on the impact of its 7% workforce reduction.

  • Fortune Brands (FBIN): Activist investor Ed Garden (Trian) acquired a stake and is demanding a CEO change, citing a rushed leadership succession process.


■ Airlines & Transport

  • Flight Cancellations: A massive snowstorm in the Northeast (20 inches in Long Island) grounded over 6,300 flights between yesterday and today.

  • Affected: United (UAL), American (AAL), Delta (DAL).



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